Figures
Effect of downregulation
Many signaling receptors are internalized faster when they are bound to their ligand—a phenomenon known as downregulation. The figure shows the effect of downregulation on the response of the epidermal growth factor receptor to time-varying ligand concentrations. Computational analysis reveals that downregulation enhances the accuracy of signaling receptors. (See Shankaran et al, e101).
Image Credit: Figure was made using the MATLAB software.
Citation: (2007) PLoS Computational Biology Issue Image | Vol. 3(6) June 2007. PLoS Comput Biol 3(6): ev03.i06. https://doi.org/10.1371/image.pcbi.v03.i06
Published: June 29, 2007
Copyright: © 2007 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Many signaling receptors are internalized faster when they are bound to their ligand—a phenomenon known as downregulation. The figure shows the effect of downregulation on the response of the epidermal growth factor receptor to time-varying ligand concentrations. Computational analysis reveals that downregulation enhances the accuracy of signaling receptors. (See Shankaran et al, e101).
Image Credit: Figure was made using the MATLAB software.