Figures
Rearrangement of protein structure
Subtle structural changes lead to distinct packing of the protein core. These changes appear due to accumulating mutations in the closely related homologous protein families. These random mutations in the ancestor protein (top) can lead to the rearrangement of the protein structure (bottom), which results in the formation of a distinct fold family (see Ding and Dokholyan).
Image Credit: Protein structures visualized with PyMOL software. Design by Nikolay V.
Citation: (2006) PLoS Computational Biology Issue Image | Vol. 2(7) July 2006. PLoS Comput Biol 2(7): ev02.i07. https://doi.org/10.1371/image.pcbi.v02.i07
Published: July 28, 2006
Copyright: © 2006 Ding et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Subtle structural changes lead to distinct packing of the protein core. These changes appear due to accumulating mutations in the closely related homologous protein families. These random mutations in the ancestor protein (top) can lead to the rearrangement of the protein structure (bottom), which results in the formation of a distinct fold family (see Ding and Dokholyan).
Image Credit: Protein structures visualized with PyMOL software. Design by Nikolay V.