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PLoS Computational Biology Issue Image | Vol. 1(3) August 2005

Representation of capturing aggregation-prone protein conformations using computer simulations

The cover image depicts a rendering of a Beta-helix structure formed by a polyglutamine peptide, putatively implicated in numerous protein-aggregation diseases. The merged image of the eye, the polyglutamine structure, and the simulation program code represents the ability to capture aggregation-prone protein conformations using computer simulations. (see Khare et al)

Image Credit: Image by Nikolay V. Dokholyan; polyglutamine structure visualized with PyMOL software.

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Representation of capturing aggregation-prone protein conformations using computer simulations

The cover image depicts a rendering of a Beta-helix structure formed by a polyglutamine peptide, putatively implicated in numerous protein-aggregation diseases. The merged image of the eye, the polyglutamine structure, and the simulation program code represents the ability to capture aggregation-prone protein conformations using computer simulations. (see Khare et al)

Image Credit: Image by Nikolay V. Dokholyan; polyglutamine structure visualized with PyMOL software.

https://doi.org/10.1371/image.pcbi.v01.i03.g001