Peer Review History

Original SubmissionNovember 21, 2025

Attachments
Attachment
Submitted filename: 148168_1_rebuttal_3553035_t4h3ks.pdf
Decision Letter - Paolo Milazzo, Editor

PCOMPBIOL-D-25-02445

Unveiling Gene Perturbation Effects through Gene Regulatory Networks Inference from single-cell transcriptomic data

PLOS Computational Biology

Dear Dr. Martello,

Thank you for submitting your manuscript to PLOS Computational Biology. After careful consideration, we feel that it has merit but does not fully meet PLOS Computational Biology's publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Mar 13 2026 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at ploscompbiol@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pcompbiol/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

* A letter that responds to each point raised by the editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'. This file does not need to include responses to formatting updates and technical items listed in the 'Journal Requirements' section below.

* A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

* An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, competing interests statement, or data availability statement, please make these updates within the submission form at the time of resubmission. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

We look forward to receiving your revised manuscript.

Kind regards,

Paolo Milazzo

Academic Editor

PLOS Computational Biology

Mark Alber

Section Editor

PLOS Computational Biology

Additional Editor Comments:

One of the reviewers asks for some improvements, mostly as regards presentation aspects and justification for some methodological choices. The authors should address these requests in a new version of the paper. The reviewer also suggests the authors to adopt a different packaging for the source code. This is a good suggestion to improve the usability of the code, but not mandatory for the acceptance of the paper.

Journal Requirements:

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Authors:

Please note here if the review is uploaded as an attachment.

Reviewer #1: The authors have adequately addressed my concerns in this revised version of the manuscript.

Reviewer #2: My comments have been uploaded as an attachment.

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Have the authors made all data and (if applicable) computational code underlying the findings in their manuscript fully available?

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: No

Reviewer #2: No

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Attachments
Attachment
Submitted filename: corridori-et-al-review.pdf
Revision 1

Attachments
Attachment
Submitted filename: Response to reviewers IGNITE 2026.pdf
Decision Letter - Paolo Milazzo, Editor

Dear Professor Martello,

We are pleased to inform you that your manuscript 'Unveiling Gene Perturbation Effects through Gene Regulatory Networks Inference from single-cell transcriptomic data' has been provisionally accepted for publication in PLOS Computational Biology.

Before your manuscript can be formally accepted you will need to complete some formatting changes, which you will receive in a follow up email. A member of our team will be in touch with a set of requests.

Please note that your manuscript will not be scheduled for publication until you have made the required changes, so a swift response is appreciated.

IMPORTANT: The editorial review process is now complete. PLOS will only permit corrections to spelling, formatting or significant scientific errors from this point onwards. Requests for major changes, or any which affect the scientific understanding of your work, will cause delays to the publication date of your manuscript.

Should you, your institution's press office or the journal office choose to press release your paper, you will automatically be opted out of early publication. We ask that you notify us now if you or your institution is planning to press release the article. All press must be co-ordinated with PLOS.

Thank you again for supporting Open Access publishing; we are looking forward to publishing your work in PLOS Computational Biology.

Best regards,

Paolo Milazzo

Academic Editor

PLOS Computational Biology

Mark Alber

Section Editor

PLOS Computational Biology

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All reviewer comments have been fully addressed.

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