Fig 1.
Relations between cognitive-, neuronal-, and behavioral states in MCM.
Solid and dotted arrows denote causal and constitutive relations, respectively.
Fig 2.
State-space diagram with transition probabilities for Example 1.
Fig 3.
p-values for rejecting the null-hypothesis of Markovianity for each worm (and averaged across worms) as a function of the number of cognitive states.
Fig 4.
Illustration of the procedure of learning a cognitive state trajectory (see main text for details).
Fig 5.
Behavioral- and cognitive-behavioral state diagrams of the third worm (see text for details).
Arrows that account for less than 0.1% of outgoing transitions of each node have been removed to reduce clutter.
Fig 6.
Behavioral- and cognitive-behavioral state diagrams of all worms.
Arrows that account for less than 0.075% of outgoing transitions of each node have been removed to reduce clutter.
Fig 7.
Side-by-side comparison of the neuronal manifold of the third worm as learned by BunDLe-Net and its representation as a directed graph in the NC-MCM framework.
Fig 8.
Side-by-side comparison of the neuronal manifold and the cognitive-behavioral state diagram of worm 1.
Fig 9.
Side-by-side comparison of the neuronal manifold and the cognitive-behavioral state diagram of worm 2.
Fig 10.
Side-by-side comparison of the neuronal manifold and the cognitive-behavioral state diagram of worm 4.
Fig 11.
Side-by-side comparison of the neuronal manifold and the cognitive-behavioral state diagram of worm 5.
Fig 12.
Cognitive-behavioral state transition diagram of the third worm with seven cognitive states.
Fig 13.
Neuronal perturbations that, when applied during a sustained reversal, the NC-MCM framework predicts to induce a cognitive state transition that increases the probability of maintaining a sustained reversal movement (blue), initiating a ventral turn (orange), or initiating a dorsal turn (green).
Double and single markers indicate the rejection of the null hypothesis of equal means across conditions at significance levels α = 0.01 and α = 0.05, respectively. Plus signs and asterisks indicate significance tests with and without Bonferroni correction, respectively.
Fig 14.
Neuronal perturbations that, when applied during a slowing movement, the NC-MCM framework predicts to induce a cognitive state transition that increases the probability of maintaining a slowing movement (blue), initiating a forward movement (orange), or initiating a rev2 reversal (green).
Double and single markers indicate the rejection of the null hypothesis of equal means across conditions at significance levels α = 0.01 and α = 0.05, respectively. Plus signs and asterisks indicate significance tests with and without Bonferroni correction, respectively.