Fig 1.
Stimulation paradigm and evoked responses.
(A) Trial consisting of a sequence of standard tones (the target) embedded in a “cloud” of tones placed randomly in frequency and time (multitone masking). (B) Source locations of responses shown in C. (C) MEG activity of undetected (blue trace) and detected (orange trace) standard tones for both left and right auditory cortex. (D) Average of undetected and detected responses across hemispheres. (E) Difference waveform between the recorded response to the undetected and the recorded response to detected standard tones. Adapted from [26]. Negative is plotted down.
Fig 2.
The Human Neocortical Neurosolver.
Architecture / underlying connectivity of HNN model cortical column and inputs (proximal input in black and distal input in gray) [14].
Fig 3.
Current dipoles and laminar profiles.
(A) HNN simulation for the average response to the undetected target tones (dark blue trace). Input spikes are sampled from a Gaussian distribution on each trial for a total of 10 trials (gray traces). A proximal input (47.8 ms) followed by a distal input (84.3 ms) drive the network. R2 between empirical (light blue trace) and simulated data (dark blue) is 0.57 and RMSE is 0.61 nAm. (B) HNN simulation for the average response to detected target tones (dark orange traces). The same proximal and distal inputs used to model the response to undetected target tones, and an additional distal input (169.3 ms), drive the network. R2 between empirical (light orange trace) and simulated data (dark orange) is 0.95 and RMSE is 0.63 nAm. (C-D) Laminar profiles for the responses to the undetected and detected target tones. The contribution of layer 2/3 (which reflects the longitudinal currents in layer-2/3 (L2/3) pyramidal neurons only) is plotted in green and that of layer 5 (which reflects the longitudinal currents in L5 pyramidal neurons only) in magenta. Note that the model traces in panels A and B reflect the aggregate of the green and magenta traces in panels C and D. The corresponding input parameter values are displayed in Fig 4. The network from which the simulated dipole activity arises consists of 60,000 cells.
Fig 4.
Driving inputs (and parameters) used to model the responses to the undetected and detected target tones.
The model column used was the calcium model column that consists of a more biologically accurate distribution of Ca2+ channels on L5 pyramidal neurons compared to HNN’s original Jones 2009 model column.
Fig 5.
Model cortical column and Local Field Potentials.
(A) HNN provides a model cortical column that consists of a scalable, ten-by-ten pyramidal neuron and basket cell grid (the ratio of pyramidal-neuron-to-basket-cell is 3-to-1). The LFP are estimated from a linear multi-electrode array of 50 electrode contacts. (B) Simulated LFP corresponding to one of the ten undetected target tone responses. (C) Simulated LFP corresponding to one of the ten detected target tone responses.
Fig 6.
(A) Network spiking activity for undetected target tones. (B) Network spiking activity for detected target tones.