Fig 1.
A) Global archetype (combining all data) Ising connectivity. The down-trending diagonal values reflect strong inter-hemispheric homotopic connectivity. B) Difference in connectivity magnitude between the placebo and LSD archetypes, with a visible loss in homotopic connectivity (see also figures in section 5, S1 Text). C) Unsigned global archetype Ising connectivity. D) AAL connectome.
Fig 2.
Local magnetization and susceptibility as a function of temperature from Metropolis simulations with the global archetype model.
A) Local magnetization and B) local susceptibility (i.e., specific to each spin or brain parcel).
Fig 3.
Phase diagram for global archetype model as a function of temperature.
A) Global susceptibility and magnetization, B) energy and heat capacity. C) LZW complexity (ρ0) and its standard deviation, and D) BDM complexity and its standard deviation. The Metropolis algorithm has been run for 108 spin flip tests for each temperature to obtain these plots.
Fig 4.
Individual shift of Ising temperature (top), LZW (middle), and BDM (bottom) complexity induced by LSD (empirical data).
The LZW and BDM estimates here are computed from the experimental fMRI BOLD data times series. A, C, E) Box plots of the metrics (temperature, LZW and BDM complexities) for each subject under the effect of LSD and placebo (one star: p < 0.05, four stars: p < 0.0001). B, D, F) Bar plots of the differences in metric (temperature, LZW and BDM complexities) between LSD and placebo for each subject. The dashed line in each plot represents the mean of the metric.
Fig 5.
Individual shift of LZW (top row) and BDM (bottom) complexity in LSD and placebo conditions estimated from synthetic data generated by the archetype model.
Here we derive complexity estimates from synthetic data generated by the individualized archetype models for each subject. A, C: Box plots of the metrics for each subject under the effect of LSD and placebo. B, D: Bar plot of the differences in metrics between LSD and placebo for each subject. The dashed line represents the mean of the metric (three stars: p < 0.001, four stars: p < 0.0001).
Table 1.
Summary statistics of different metrics.
Change in Ising temperature and complexity metrics in the LSD condition relative to the Placebo condition.
Table 2.
Pearson correlation between different metrics.