Fig 1.
Schematic diagram of the data generating processes (DGPs) explored in this paper.
This diagram aims to portray the DGPs as the ensemble of two components: a measurement or observational model (ellipse) and a process model (rounded rectangle). For instance, DGP1 is the amalgamation of the measurement model OM1 and the process model PM1. The process model is in turn the ensamble of two structures: a within-host profile (hexagon) and a time-dependent transmission rate (rhombus). Whereas all process models share a common within-host profile (SEI3R), they differ in the formulation of the transmission rate: Geometric Brownian Motion (GBM), Cox-Ingersoll-Ross (CIR), and nth-order exponential smoothing (NTH-SM). The inference method employed on each DGP depends upon the nature of the process model (Iterated Filtering + Particle Filter for stochastic structures and Hamiltonian Monte Carlo for deterministic ones).
Fig 2.
(A) Daily number (rhombus-shaped points) of COVID-19 cases detected during Ireland’s first wave, from the 29th of February 2020 to the 17th of May 2020. The x-axis indicates the date in which the infected individuals were swabbed. The line represents the smoothed trend (via LOESS method) from the data (B) Weekly number of COVID-19 cases detected in during Ireland’s first wave. The x-axis indicates the number of weeks since the first case was detected. (C) Apple data for Ireland from the 29th of February 2020 to the 17th of May 2020. Points represent the normalised amount of daily requests for driving directions. These indexes are normalised to the value on the 28th of February 2020. We highlight points every 7 days. These highlighted points are used to calibrate DGP1 and DGP2. The line represents the smoothed trend (via LOESS method) from the data. (D) Normalised amount of daily requests for driving directions at the end of each week starting from the 29th of February 2020. These bars correspond to the highlighted points in C.
Fig 3.
(A) 200 simulations from a transmission rate described in terms of Geometric Brownian Motion. We generate these simulations from DGP1’s Maximum Likelihood Estimate (MLE) using the Euler-Maruyama algorithm. The highlighted trend corresponds to the mean trajectory path. (B) 200 simulations from a transmission rate described in terms of the Cox-Ingersoll-Ross model. We generate these simulations from DGP2’s Maximum Likelihood Estimate (MLE) using the Euler-Maruyama algorithm. The highlighted trend corresponds to the mean trajectory path.
Table 1.
Measurement model candidates.
Fig 4.
In these three figures, the predicted values stem from DGP1’s filtering distribution. Further, in the LHS, the solid line indicates the median, and the darker and lighter ribbons represent the 50% and 95% CI, respectively. (A) Comparison between the predicted incidence (solid line and ribbons in the LHS; violin plots in the RHS) and weekly detected cases from Ireland’s first COVID-19 wave (rhombi in the LHS; horizontal dotted lines in the RHS). (B) Comparison between the predicted relative transmission rate (solid line and ribbons in the LHS; violin plots in the RHS) compared to Apple’s mobility indexes in Ireland (points in the LHS; horizontal dotted lines in the RHS). (C) Predicted effective reproduction number (solid line and ribbons in the LHS; violin plots in the RHS). Horizontal dashed lines denote the epidemics threshold.
Fig 5.
In these three figures, the predicted values stem from DGP2’s filtering distribution. Further, in the LHS, the solid line indicates the median, and the darker and lighter ribbons represent the 50% and 95% CI, respectively. (A) Comparison between the predicted incidence (solid line and ribbons in the LHS; violin plots in the RHS) and weekly detected cases from Ireland’s first COVID-19 wave (rhombi in the LHS; horizontal dotted lines in the RHS). (B) Comparison between the predicted relative transmission rate (solid line and ribbons in the LHS; violin plots in the RHS) compared to Apple’s mobility indexes in Ireland (points in the LHS; horizontal dotted lines in the RHS). (C) Predicted effective reproduction number (solid line and ribbons in the LHS; violin plots in the RHS). Horizontal dashed lines denote the epidemics threshold.
Fig 6.
Comparison between expected values and data. On the LHS, for each model, we show 100 overlapped simulations of the predicted incidence against daily case counts. On the RHS, for each model, we show 100 overlapped simulations of the predicted relative transmission rate against Apple’s mobility data. In this plot, we estimate the predicted values from the posterior distribution of each of the DGP3’s nine candidate process models.
Fig 7.
Comparison of predicted latent states.
In this plot, predicted values stem either from the filtering distribution (DGP1 and DGP2) or the posterior predictive distribution (DGP3). Here, DGP3’s process model corresponds to the structure that describes the transmission rate in terms of a 4th-order information delay. Further, solid lines indicates the median, and the ribbons represent the 95% CI. (A) Comparison between predicted incidences by DGP (solid lines and ribbons) and weekly detected COVID-19 cases (rhombi) in Ireland during the first wave. (B) Comparison between predicted relative transmission rates by DGP (solid lines and ribbons) and Apple’s driving mobility indexes (points) in Ireland during the first wave. (C) Predicted effective reproductive numbers by DGP (solid lines and ribbons) during Ireland’s first COVID-19 wave. The dashed horizontal line denotes the epidemics threshold.