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Fig 1.

Scree-, score-, and loading plots for the full effect matrix for time + time*treatment.

Abbreviations: CTX: Chemotherapy, B: Bevacizumab, GPC: Glycerophosphocholine, PC: Phosphocholine.

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Fig 2.

Score plot for PC1 for the effect matrix for time + time*treatment, augmented with random effects (continuous lines) and both random effects and residuals (dashed lines). Only a random subset of patients with complete data are included in the plot. Orange: Chemotherapy + Bevacizumab. Blue: Chemotherapy only.

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Fig 3.

Scree-, score-, and loading plots for the effect matrix for time in the bariatric surgery data.

Abbreviations: PC: principal component, MSM: methylsulfonylmethane.

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Fig 3 Expand

Fig 4.

Scree-, score-, and loading plots for the effect matrix for the treatment + time*treatment interaction effect.

Abbreviations: PC: principal component, MSM: methylsulfonylmethane.

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Fig 4 Expand