Fig 1.
ViralLink workflow overview.
Fig 2.
Causal network of SARS-CoV-2-infected NHBE cells.
A) Signalling flows from left to right: SARS-CoV-2 proteins/protein fragments (red triangles), human binding proteins (yellow parallelograms), intermediary signalling proteins (blue circles), transcription factors (green rectangles) and differentially expressed genes (grey rhombuses). Where a human protein/gene is acting in multiple layers of the network, it is only visualised once based on the following priority: DEGs, binding proteins, TFs, signalling proteins. B) Results of betweenness centrality analysis, which measures the global importance of nodes (molecules) in the network. Nodes coloured based on their betweenness centrality parameter, with the gene names of the 10 highest scoring (most central) nodes overlaid. DEGs have log2 fold change ≥ |0.5| and adjusted p value ≤ 0.05.