Table 1.
Description of cohorts included in adipocyte morphology phenotyping and meta-analysis.
| Histology sample sizes denote the number of tissue samples available in either the subcutaneous (subq) or visceral (visc) depots, after image quality control was complete (see Methods).
Fig 1.
Overview of the pipeline to obtain adipocyte areas.
Fig 2.
Comparison of Adipocyte U-net-estimated adipocyte area with Adiposoft and CellProfiler-estimated adipocyte area across fatDIVA and MOBB cohort.
Estimates from our Adipocyte U-Net and from Adiposoft or CellProfiler are highly correlated, indicating concordance between our method and the two current gold standards for measuring cell morphology. The time necessary to compute these estimates with Adipocyte U-net was several orders of magnitude faster than the time required by Adiposoft/CellProfiler to generate the same measures.
Table 2.
Summary of adipocyte measurements per cohort.
Fig 3.
Mean adipocyte area across adipose depots (subcutaneous: blue, visceral: green) per sample.
Visceral adipose tissue tends to have a bimodal distribution of mean adipocyte areas as compared to subcutaneous adipose tissue.
Fig 4.
Association between mean adipocyte area and BMI across subcutaneous and visceral adipose tissue depots.
We observe a strong correlation between BMI and mean adipocyte size across both subcutaneous and visceral depots in all cohorts.