Fig 1.
Schematic of the platelet network from [9, Figure 1].
Fig 2.
We see the active external stimuli u1 (activating P2Y12) and u2 (activating P2Y1) where the others are not active.
The others are u3 activating PTP, u4 inhibiting ThromR and u5 inhibiting Akt if active. The time is on the abscissa (t) and the activity level (A) is on the ordinate. The original Matlab output is without axis labeling.
Fig 3.
We have the activity levels of P2Y12 (x1), of P2Y1 (x2) and of integrin (x6) where we see the decay of the receptors’ activity while the activity level of integrinconverges to 90%.
The time is on the abscissa (t) and the activity level (A) is on the ordinate. The original Matlab output is without axis labeling.
Fig 4.
Schematic of the CD4+ T-helper and Treg network from [10, Figure 2].
Fig 5.
External stimuli that cause a switch from Th17 to Treg where in this figure there is a minimal set of external stimuli that performs the desired switch calculated by Algorithm 3 where u4 activates IL-2, u7 activates TGF-β andu8 inhibts RORγt.
The time is on the abscissa (t) and the activity level (A) on the ordinate. The original Matlab output is without axis labeling.
Fig 6.
External stimuli that cause a switch from Th17 to Treg where in this figure we calculated with Algorithm 1 further external stimuli that support the desired switch caused by the external stimuli depicted in Fig 5 where u4 activates IL-2, u7 activates TGF-β, u8 inhibits RORγt, u9 inhibits IL-6 and u10 inhibits IL-6R.
The time is on the abscissa (t) and the activity level (A) on the ordinate. The original Matlab output is without axis labeling.
Table 1.
Validation for the T-helper cell model.