Fig 1.
Schematic of the compartment model.
The main model is presented in Eq (1). The extended model, that includes resistance to treatment, is represented in dashed lines in the schematic and is detailed in Eq (6).
Fig 2.
Evaluation of the efficacy of TOL and ROL in acute and chronic infections.
Equilibrium values of the incidence (A, D), prevalence (B, E), and fraction of mortality due to infection (C, F), which normalizes the disease-induced mortality by the overall mortality. These epidemiological measures are plotted against the fraction of the population that receives treatment. The effect of TOL is displayed in light red, that of ROL in black, and that of TOL and ROL combined in blue. Parameters for both acute and chronic infections are given in the Methods section.
Fig 3.
All pathogens become resistant to treatment for large coverage of the ROL treatment.
Fraction of the population infected by the resistant pathogen over the total infected population (A, E), and equilibrium values of the incidence (B, F), prevalence (C, G), fraction of mortality due to infection (D, H). These epidemiological measures are plotted against the fraction of the population that receives treatment. The effect of ROL is displayed in black, that of TOL and ROL in blue. TOL, which does not lead to resistance, is represented in red and is reproduced for comparison from Fig 2. Parameters for both acute and chronic infections are given in the Methods section.