Fig 1.
Pearson correlation of tissue-specificity between a) orthologs and b) paralogs. a) Human ortholog vs. one-to-one ortholog in another species; b) highest expressed paralog vs. lowest expressed paralog in human, for different duplication dates.
Fig 2.
Pearson correlation of tissue-specificity focusing on a) human and b) mouse. X-axis, divergence time in million years between the genes compared; Y-axis, Pearson correlation between values of τ over genes. In red, the correlation of orthologs between the focal species and other species; representative species are noted above the figure; there are several points when there are several datasets for a same species, e.g. four for mouse (Table 1); the size of red circles is proportional to the number of tissues used for calculation of tissue-specificity. In blue, the correlation of paralogs in the focal species, according to the date of duplication; representative taxonomic groups for this dating are noted under the figure; the size of blue circles is proportional to the number of genes in the paralog group.
Fig 3.
Distribution of tissue-specificity in paralogs compared to an outgroup ortholog.
For each graph, paralogs of a given phylogenetic age are compared to the closest outgroup un-duplicated ortholog; thus these paralogs are "in-paralogs" relative to the speciation node, and are both "co-orthologs" to the outgroup. X-axis, τ of unduplicated ortholog. Y-axis, τ of paralogs. Blue points are values for the paralog with highest maximal expression of the pair of paralogs, orange points are values for the other.
Fig 4.
Difference of tissue-specificity between orthologs and paralogs.
Each bar represents the number of gene pairs of a given type for a given phylogenetic age, for which both genes of the pair are tissue-specific (τ > 0.8). In dark color, the number of gene pairs specific to the same tissue; in light color, the number of gene pairs specific to different tissues. Orthologs are in red, in the left panel, paralogs are in blue, on the right panel; notice that the scales are different for orthologs and for paralogs. Orthologs are one-to-one orthologs to human and paralogs are within-species paralogs in human. The overall proportions of pairs in the same or different tissues are indicated for orthologs and paralogs; in addition, for paralogs the proportion for pairs younger than the divergence of tetrapods (whole genome duplication) is also indicated.
Table 1.
Datasets used in the paper.