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Figure 1.

Shows popular data integration approaches, with examples, for resources that have implemented these approaches.

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Table 1.

Some of the major successful and recognized examples of data integration.

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Figure 2.

Schema of the four major roles in data integration in a federated system.

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Figure 3.

Example of a genome reference source representing a database including a list of genome features.

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Figure 4.

Example of a genome reference source representing a database including a list of nucleotide sequences.

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Figure 5.

Example of the card for the “Registry” after genome sources have been registered.

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Figure 6.

Example of the graphical representation someone playing the “Client” role could come up with.

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Figure 7.

Game card used to play the role of the “User” including a selection of genome queries.

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Figure 8.

Example of a DAS genome client (Dalliance) displaying positional annotations from several sources (e.g., Ensembl, HGNC, Agilent probesets, and Toronto CNVs) [33].

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