Table 1.
Eukaryotic Species Had in the Recent Evolutionary Past a Fast Rate of Change of Interactions
Figure 1.
Preferential Interaction Turnover Is Observed in All Eukaryotic Interactomes
We have binned proteins according to their average number of interactions and calculated for each bin the rate of change of interactions. There is a very strong correlation between the degree of connectivity and the interaction turnover.
Table 2.
Domains Found to Contribute to the Fast Rate of Change of Interactions in at Least Three of the Four Species Studied
Figure 2.
Protein Binding Domains with Many Structural Interactions Observed Have a Higher Link Turnover
We have grouped proteins containing domains with increasing observed structural interactions with other domain types and calculated for each bin the rate of change of interactions. Proteins containing domains known to interact with many other different domains have a higher rate of change of interactions than proteins containing domains with few known interactions.
Table 3.
Specificity of Protein Binding Is an Important Factor Determining the Rate of Change of Interactions
Figure 3.
Biological Process Can Determine Link Dynamics Independently of the Number of Interaction Partners
We have binned proteins according to the biological processes, defined in Gene Ontology, and calculated for each bin the average number of interactions and average rate of change of interactions (see Materials and Methods). The black line represents the expected rate of change for proteins with increasing numbers of interactions.
Table 4.
Biological Processes with Above-Average Rate of Change of Interactions