The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic sequence
Fig 4
The temporal behaviors of the 10 metagenes identified by NMF.
The behaviors inferred from the genome-wide gene expression time series data (Fig 1A) using NMF are shown in the first two columns. The temporal behavior of each metagene is shown in red. The temporal expression patterns, with maximum expression scaled to 1, of the transcripts having the highest 200 weights for each behavior are shown in black. The last two columns illustrate the reconstruction of the expression pattern of Cx3cr1 by the sequential accumulation of the weighted behaviors , where M is the row number, Hm(t) is the behavior of metagene m, and Wgm is Cx3cr1’s weight for the mth behavior. Cx3cr1’s expression pattern is shown in black and the weighted sum accumulating sequentially from the top to bottom is shown in red.