The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic sequence
Fig 2
PUER cell differentiation is punctuated by two sharp transitions.
A,B. Pearson correlation coefficient between genome-wide gene expression at each pair of time points in GCSF (A) or IL3 (B) conditions during PUER differentiation (Fig 1A) is plotted as a heatmap. C. Principal components analysis of all the samples. Gene expression was standardized to have zero mean and unit variance. The samples are plotted along the first two principal components, PC1 and PC2, that account for 25% of the total variance.