CASER: A semi-supervised model with multi-omics data integration prioritizes cancer-associated epigenetic regulator genes
Fig 6
Evaluation of the identified cERs by a published ER CRISPR-screen dataset and the DepMap gene essentiality screen dataset.
The robust rank aggregation (RRA) scores of negative selections are shown for different gene sets in (A) LNCaP and (B) MDA-MB-231 cells. The Chronos dependency scores are shown for different gene sets in (C) LNCaP and (D) TNBC cancer cell. The RRA scores of negative selection were calculated using MAGeCK. The higher -log10(RRA) values indicate a greater effect on cell survival after gene knockdown. The lower DEMETER and Chronos score indicate a greater effect on cell survival after gene knockdown. The genes in this analysis are both cancer genes and ERGs. Non-cancer ERs refer to the ER genes that are also neutral genes. P-value is calculated by Wilcoxon rank-sum one-tailed test.