A three-dimensional shear dependent continuum model of platelet aggregation under flow
Fig 7
3D rendering of numerically simulated clots and experiment comparisons.
Each row shows a side view (left) and a top-down view (right) of simulated (left two columns) and experimental (right two columns) vWF-mediated platelet aggregation after 450 seconds. Rows A and B correspond to simulations with an initial wall shear rate of 300 s-1, with and without activation by ADP, respectively. Rows C and D correspond to simulations with an initial wall shear rate of 1500 s-1, with and without activation by ADP, respectively. Red in the simulations represents the sum of all activated platelets and the green are bound unactivated platelets. Red and green in the experiments is as before, DiOC6 labeled and anti-CD62P (marked for granule secretion), respectively.