A three-dimensional shear dependent continuum model of platelet aggregation under flow
Fig 5
3D reconstruction of platelet aggregates from confocal microscopy.
Results at 5 minutes of perfusion over collagen related peptides at 300/s (A,B) and 1500/s (C,D) with a vehicle control (A,C) or inhibition (B,D) of amplification loops (indomethacin, 2Me-SAMP, MRS2719). DiOC6 labels all platelets and anti-CD62P labels activated platelets that have secreted -granules. Flow is from upper-left to lower-right. Dimensions of box is length = 333
m, width = 330
m, and height = 30
m.