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A multi-omics framework for survival mediation analysis of high-dimensional proteogenomic data

Fig 2

A causal diagram to describe the framework of the mediation analysis of high-dimensional mediators with multivariable exposures and survival endpoint.

Here, the two types of effects are assessed: (1) the global indirect effect between and T, and specific mediation effect that is mediated by a mediator variable for each proteome that is selected from the penalized variable selection (nodes colored in blue) and (2) the direct effect between multivariable exposures RNA-Seq gene expressions (nodes colored in orange) and survival outcome T (a node colored in red).

doi: https://doi.org/10.1371/journal.pcbi.1014217.g002