VUStruct: A compute pipeline for high throughput and personalized structural biology
Fig 4
Screenshot of a section of the VUStruct results page, which foreach structural model shows the results of the ΔΔG and PathProx calculations, highlighted in red, along with associated statistics to judge reliability.
Each structure is displayed in a customized and interactive NGL Viewer [19] session. This view can be used to understand the structural context of the variant (highlighted here with a gray text pop-up. For example, one can display all pathogenic and likely pathogenic ClinVar variants (shown as red spheres), or color the model according to AlphaFold confidence or by PathProx score (from low- blue, to high - red - as shown above). Figs to illustrate a structural mechanistic hypothesis can be generated quickly from these images.