Phase-field modeling of border cell cluster migration in Drosophila
Fig 4
Impact of traditional chemical force term (Fchem).
(a) 2D steady-state distribution of chemoattractant concentration c(x,y) in the egg chamber domain. (b) Receptor activation in response to the chemoattractant concentration increases along the anterior-posterior axis and saturates near the posterior at the oocyte. (See S1 Fig for chemoattractant distribution without impact of radial variation)(c)-(e) Time evolution of border cell cluster migration, simulated using the phase field model in Eq (9) with Fchem, Eq (12). The border cell cluster (green) initiates at the anterior end and migrates toward the posterior oocyte in response to a chemoattractant gradient. The green arrows in the cluster indicate () in Eq (12). Cell boundaries are represented by phase field contours (red for nurse cells, blue oocyte, and black epithelial layer) at the
level. The parameters are set as follows:
,
, s = 1, and
. The parameters used are consistent with those in Fig 3. (See S2 Fig for migration without impact of radial variation).