Subunit-specific behavioral modulation of sensory tuning in the visual cortex
Fig 5
Behavioral modulation of orientation-selective cells.
a) Left panel: joint distribution of stimulus directions preferred by subunits in two-subunit neurons. Right panel: histogram of angular separation (distance) between stimuli preferred by individual subunits in two-subunit neurons. b) Histogram of log-ratios of modulator strength (stronger to weaker). The mean equal to 3.36 was computed before logarithmic transform. c) Histograms of correlations between modulators in two-subunit neurons. Orange, grey and blue correspond to the original data, bootstrap tuning curves without modulation and bootstrap tuning curves with shared modulation respectively. Data distribution is significantly different from both simulated datasets (KS-test, both p-values < 0.001). d) Histograms of correlations between modulators and running speed in stronger and weaker subunits (left and right panels respectively). Orange, grey and blue correspond to the original data, bootstrap tuning curves without modulation and bootstrap tuning curves with shared modulation respectively. Correlation distributions are significantly different from bootstrap without modulation in both panels (KS-test, p-value < 0.001) and not significantly different from bootstrap with shared modulation (KS-test, p-value > 0.1). Correlation distributions for stronger and weaker modulators are not significantly different (KS-test, p-value = 0.24). e) Scatter plot of modulator correlations with running speed. Each gray dot corresponds to a single neuron. Thin black lines within the plot denote 5th (left and bottom line) and 95th (right and upper line) percentiles of modulator-speed correlations computed with bootstrap samples without modulation. Darker points with Roman numerals correspond to identically labeled tuning curves in panel f. f) Example direction-speed tuning curves (grayscale heatmaps) and corresponding fitted modulators of stronger and weaker subunits (orange and gray lines respectively). Correlations of the stronger and weaker modulator with the running speed are denoted as in orange and gray respectively. Roman numerals correspond to points marked in panel, e. g) The same as e but for randomly permuted modulators (left) and simulated joint modulators (right). h) Proportions of cells in different regions of the correlation plane for real data (top row), bootstrap samples without modulation (second row from the top) and bootstrap samples with simulated joint modulators (third row from the top). Color legend of areas on the correlation plane (as in e-f) is depicted in the bottom row.