Rules railroad: Syntax-inspired diagrams for visualizing and understanding rule-based model specifications
Fig 4
Irreversible rules for binding (A) and unbinding (B) of the SH2 domain of Grb2 to the Y1068 site of EGFR in the phosphorylated (“p”) state.
The SH3 site of Grb2 must be unbound for the interaction to occur. Other sites on EGFR are not constrained—they may be in any allowable state and may be either bound or unbound.