A multimodal spatial atlas of transcriptomic, morphological, and electrophysiological cell type densities in the mouse brain
Fig 6
Brain region cell types composition.
A. UMAP projection of brain regions based on (i) me-type and (ii) t-type density profiles. Each point represents one brain region, positioned according to its high-dimensional composition projected into a two-dimensional UMAP space (UMAP1 and UMAP2 are arbitrary axes that preserve relative similarity, not direct biological variables). Colors indicate k-means cluster assignments, which group regions with similar cellular compositions. (iii) Overlap matrix showing the percentage of brain regions shared between me-type based clusters (rows) and t-type based clusters (columns), with color intensity reflecting overlap magnitude. B. Exemplar region profiles: pie charts show the me-type composition of me-types in six representative brain regions chosen from distinct clusters. Only me-types comprising more than 5% of the brain region are displayed for clarity. Excitatory me-types are shown in shades of red, and inhibitory me-types in shades of blue. A complete color legend for all me-types is provided in the Supplementary Information.