Deconvolving cell-type-specific gene expression profiles from bulk RNA-seq samples
Fig 1
The input is the gene expression vector of a bulk sample. BLUE contains two branches. The top branch in the figure is a U-Net model to output cell-type-specific gene expression profiles. The bottom branch in the figure is a 5-layer fully connected MLP to output cell-type proportions. The two branches are jointly trained end-to-end on pseudobulk RNA-seq samples simulated from scRNA-seq reference datasets.