Zero-shot prediction of drug responses using biologically informed neural networks trained on phosphoproteomic timeseries
Fig 5
A. Heatmap showing the overlap between predicted kinase–substrate pairs and validated pairs from OmniPath. Red indicates validated overlaps, while grey marks pairs predicted by the model but not present in OmniPath. Predictions are defined as phosphosites differentially expressed in in silico perturbations that are directly connected to the drug target in the OmniPath network. B. Overlap between differentially expressed phosphosites in the experimental data and validated kinase–substrate pairs for two drugs with available measurements.