Role of fast-spiking interneurons in modulating across-trial variability and within-trial correlations in the striatum
Fig 5
Possible functional consequences of FSI modulations.
(A) During the learning phase, the high-sharing of FSI induces variable population responses across trials, which facilitates exploration behavior; during the performance phase, FSIs are functionally decoupled, leading to stable responses across trials, which facilitates exploitation behavior. (B) Different groups of MSNs receive cortical inputs from distinct but overlapped sources. In contrast to MSNs, FSIs receive inputs from both sources. Whether the signals get integrated (high correlation between the activities of two MSN groups) or differentiated (low correlation) is modulated by the sharing level of FSI projections to MSNs.