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Role of fast-spiking interneurons in modulating across-trial variability and within-trial correlations in the striatum

Fig 4

Downstream effect of FFI sharing on a GPe neuron.

(A) We describe the state of MSN population activity as average pairwise correlation (x-axis) and across-trial variability (y-axis). Each line starts at a point indicating average pairwise correlation and across-trial variability for and ends at a point indicating average pairwise correlation and across-trial variability for Nfsi = 250. A filled circle marks the ending of a line. Each line corresponds to a specific input correlation (see Fig 3A). The correlation level and across-trial variability of population firing increase with stronger sharing of feedforward inhibition (Nfsi changing from 250 to 25). (B) The bursting index (x-axis) and across-trial variability (y-axis) of a GPe neuron in response to MSNs’ activity during evoked states. Each line starts at a point indicating average bursting index correlation and across-trial variability for and ends at a point (marked with a filled circle) indicating average bursting index and across-trial variability for Nfsi = 250.

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1014099.g004