Role of fast-spiking interneurons in modulating across-trial variability and within-trial correlations in the striatum
Fig 3
Modulation of correlation by sharing of FSIs in the striatum during evoked states.
(A) Effective correlation settings for the cortical inputs. (B) Output statistics of MSNs for Nfsi = 0. Left: output correlation (averaged across 100 trials for each input setting) of MSNs’ spiking activity. The x-axis denotes mean pairwise correlation within the MSN group (Wmsn) while the y-axis denotes mean pairwise correlation between two MSN groups (Bmsn). The color corresponds to A. Right: all trials of output correlations. (C) Each subplot compares the correlation of MSN activities between the control case (no FSI) and the studied case (a certain number of FSIs or degree of FFI sharing). Each line corresponds to a particular input correlation (color code same as in panel A). The starting and ending points of the lines denote the trial-averaged output correlation for Nfsi = 0 and Nfsi > 0, respectively. From left to right, the value decreased from Nfsi = 250 to Nfsi = 25 (or the sharing of FFI increased). (D) Same as in panel C, but in this case the starting point of each line is the output correlation measured for Nfsi = 250.