PepLM-GNN: A graph neural network framework leveraging pre-trained language models for peptide-protein binding prediction
Fig 4
Application of PepLM-GNN in virtual peptide drug screening.
(A) Relative changes in the predicted binding probability of RBBp4 and SALL4 peptide alanine mutants by PepLM-GNN compared with experimentally measured changes in binding free energy. (B) Protein subgraphs interacting with FFW peptides extracted using the GNNExplainer tool. (C) Functional enrichment analysis of proteins interacting with the FFW peptide.