Deciphering the cardiac neuron landscape in heart failure patients
Fig 5
Identifying the transcriptional regulatory mechanism of neuronal cell in heart failure.
(a) Five regulons with higher transcriptional activity in N4-ALK cells. (b) Differential expression of transcription factors ATF1, NRL, PAX3, RFX1, and RXRG in different cell types. (c) Transcriptional networks consisting of the five transcription factors and their top ten targets. (d) The density plot showing the enriched regions of RXRG regulon activity on the neuronal map. (e) The expression of RXRG across neuronal subsets. (f) Differential expression of RXRG in heart tissue between heart failure group and healthy group both in GSE165303 and GSE57345. (g) Pearson correlation between the expression of RXRG and PTPRZ1 both in GSE165303 and GSE57345. (h) Differential expression of RXRG in response to LVAD before and after receiving LVAD implantation. (i) Differential expression of RXRG in cardiac neurons with or without response to LVAD after receiving implantation. (j) The crosstalk between cardiac neurons and fibroblasts mediated by overexpression of RXRG in heart failure. Images provided by Servier Medical Art (https://smart.servier.com), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). In (f), (h), and (i), Wilcoxon rank-sum test was used.