Deciphering the cardiac neuron landscape in heart failure patients
Fig 4
Cellular crosstalk between neurons and fibroblasts.
(a, b) Differences in the strength of interactions between patients with DCM and healthy donors (a) and patients with HCM and healthy donors (b). The red arrow pointed out the cell types of N4-ALK on X-axis and fibroblasts in Y-axis. Black box marked the differential interaction between these two cell types. (c) Pearson correlation between the percentage of fibroblasts and the percentage of each neuronal subset in patients with heart failure. (d) Dot plot showing the communication between fibroblasts and neuronal subsets mediated by specific ligand-receptor pairs. (e) Differential expression of PTPRZ1 and ALK in neurons between the heart failure group and the healthy group. (f) Differential expression of PTPRZ1 before and after receiving implantation in the LVAD responsive group. In (e) and (f), Wilcoxon rank-sum test was used.