Deciphering the cardiac neuron landscape in heart failure patients
Fig 3
The transcriptional heterogeneity of neuronal subsets.
(a) GO enrichment analysis of differentially expressed genes in N1-XKR4, N2-OGFRL1, and N4-ALK, respectively. The q value represented P value adjusted by Benjamini & Hochberg (BH). (b) Pseudo time analysis of reshaping neuronal cells over time. (c) Different cellular states divided by four branch nodes. (d) Evaluation of the differentiation ability on each neuronal cell. The color ranging from blue to red represented an increase in differentiation ability. (e) The composition of cellular states in heart failure and healthy conditions respectively. (f) Left Molecular changes along the trajectory conducted by branch three. Right GO enrichment analysis on each gene cluster with showing the top three pathways.