Thrombin activity confinement and dense granule release drive the dynamics of arterial thrombus
Fig 6
Simulation of thrombus growth after the circular vessel injury in 3D.
A) Illustration of the idea suggesting the importance of the large thrombus shell for hemostasis in response to the penetrating injury. Top row: three stages of thrombus formation after the non-penetrating injury. Thrombus becomes smaller due to the decrease in ADP concentration. Thrombus shell is shown in orange, while the core is shown in green. Bottom row: three stages of the hemostatic plug formation upon complete vessel dissection: formation of a large shell allows the thrombus to reach itself from the opposite sides and thus completely occlude the injured vessel. B)-E) 2D axisymmetric computational domain consisted of a cylinder representing the vessel and the injury site zone. Vessel diameter was 36 microns, vessel length was 3060 microns. Injury zone was represented as a torus with an elliptic section with semiaxes of 13.5 and 6 microns. B), C)- Images of thrombus in the model simulation at 40 seconds and at the moment of occlusion (42.123 s). Vessel lumen is brown, shell is blue, while the core is dark blue. Flow direction was from top to the bottom. On each image color bar shows the values of porosity corresponding to colors on this image. D) 3D view of the thrombus at the moment of occlusion. Vessel lumen is brown, shell is blue, core is dark blue. E) Simulation where ADP release from platelet dense granules was turned off. Image of the thrombus in the model simulation at 200 seconds. Vessel lumen is brown, shell is blue, while the core is dark blue. Flow direction was from top to the bottom. Color bar shows values of porosity corresponding to colors on this image.