Thrombin activity confinement and dense granule release drive the dynamics of arterial thrombus
Fig 2
Comparison between the continuum model simulations and in vivo experiments on the laser-induced thrombosis in the wild type mice.
A) Model geometry. 3D computational domain consisted of a cylinder representing the vessel and an injury site zone. Vessel diameter was 36 microns, while vessel length was 3060 microns. Injury zone was represented as an oblate ellipsoid with semiaxes of 13.5, 13.5 and 6 microns. Center of the ellipsoid was located on the vessel wall. Blue color marks the zone of thrombin generation. B) Temporal dynamics of thrombus core area and total thrombus area in vivo (data from Movie A [20], orange and red dots) and in the model simulation (green and blue dots). C) Temporal dynamics of the thrombus core area in vivo and in the model simulation (high resolution). D) Images of thrombus showing the core and a shell in the model simulation (vessel lumen is brown, shell is blue, core is dark blue). Flow direction was from top to the bottom. On each image color bar shows the values of porosity corresponding to the colors on this image. Note that thrombus core efficiently occupied the injury site zone.