TUSCAN: Tumor segmentation and classification analysis in spatial transcriptomics
Fig 4
Further subclone tree reconstruction.
(A) Spatial visualization of six tumor clones. (B) Heatmap of estimated CNPs for tumor spots. Clone 3 was further subdivided into four subclones. (C) Phylogenetic clonal tree of the tumor clones from inferred CNPs. Gray circles are unknown ancestors. The pink circle represents the original normal cells. All CNV locations of clone C are marked on the left side of the node, where the maximum CNV locations are observed. CNV locations that are unique to other clones in comparison to clone C are indicated with distinct colors. The complete CNV profile can be found in the S3 Table. (D) Visualization of the inferred trajectory. Higher pseudo-times are marked as darker colors.