Dense and distributed neuropeptide network in the nerve net of Hydra vulgaris
Fig 3
Predicted interactions between identified peptides and GPCRs in Hydra.
Binding prediction results for identified peptides and GPCRs, with top 10% highest scores highlighted by black circles. Colors represent precursors from which the respective peptides are synthesized. Prediction scores integrate results from AlphaFold and DeepTMHMM to assess expected binding potential of the receptor-neuropeptide combination within the predicted membrane location (see Methods). Note that several different receptors can bind each neuropeptide. Further, several of receptors are found to bind more than one neuropeptide and have high scores even across families, reinforcing the idea that the neuropeptide network is flexible and relies on highly distributed set of interactions.