Dense and distributed neuropeptide network in the nerve net of Hydra vulgaris
Fig 2
Identification and interspecies comparison of Hydra´s GPCRs.
Cluster analysis of major Class A GPCRs from cnidarian, bilaterian, and placozoan species, illustrating sequence similarity relationships. Each node represents a GPCR sequence, with edges indicating similarity-based connections. Different species groups GPCRs are color-coded. Orange highlights GPCRs sequences that have been deorphanized and shown experimentally to bind neuropeptides in Nematostella vectensis. These were used as a guidance to determine GPCR from Hydra vulgaris that putatively can bind neuropeptides (highlighted in green). Edges are colored by intensity. Fruchterman Reingold algorithm used for clustering with repulsion set to 40 and attraction between nodes set to 10.