From noise to models to numbers: Evaluating negative binomial models and parameter estimations in single-cell RNA-seq
Fig 3
The mRNA distribution of the telegraph model converges to that of effective NB distribution as the sum of the gene-state switching rates relative to the mRNA degradation rate () increases.
In the dashed box, we show that the effective NB distribution (blue solid line) exhibits a lower KL divergence to the telegraph model distribution compared to the Poisson approximation (orange dashed line) as grows. The distributions of the telegraph model (green dots), effective NB (blue solid lines), and Poisson (orange dashed lines) are shown for Points A-E, as indicated in the KL divergence plot. The other parameters are fixed at
and
. Point A:
, Point B:
, Point C:
, Point D:
, Point E:
.