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Assessing the impact of climate and control interventions on spatio-temporal malaria dynamics using a stochastic metapopulation model

Fig 2

Diagram of the compartmental structure of the model.

For each cluster u, the human population is divided into five classes: - susceptible to infection; - exposed to parasites that have not yet matured into gametocytes; - infected with symptoms and infectious; - asymptomatic with reduced parasitemia; and - recovered and protected from severe infection. Transitions between the human compartments are denoted by a solid arrow with rate μ, and transitions between the human and mosquito compartments are denoted by dotted lines. The chain of compartments implements a distributed time delay between infections in humans and the force of infection (the per-capita rate of infection) experienced by a susceptible individual, as described in Methods Section. The model is formalized by the stochastic differential equations (3)-(7).

doi: https://doi.org/10.1371/journal.pcbi.1014004.g002