Paraplume: A fast and accurate antibody paratope prediction method provides insights into repertoire-scale binding dynamics
Fig 5
Effect of hypermutations on paratope size in human repertoires.
Analysis for donor 326651 from [32]. (A) 2D histogram showing the relationship between the paratope size of observed antibody sequences and their inferred germline counterparts. (B) Paratope sizes of observed sequences and germline sequences grouped by amino acid mutation count bins. (C) Density of the average increase in paratope size within lineages, shown across different lineage size bins. Each density curve is fitted using all lineages in the corresponding size range. The black line indicates the median average increase in paratope size for each bin. (D) Median average increase when averaging over sequences with a fixed number of mutations within the lineage.