Putting BASIL in a BLT: A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations
Fig 5
Performance of BASIL on simulated data.
Left panels A, B, E, F show simulations in the weak selection regime; right panels C, D, G, H show simulations in the strong selection regime. A, C. Observed barcode frequency trajectories colored by fitness. B, D. Mean fitness trajectories. Grey lines show the ground truth, circles show values inferred by BASIL. E, G. F1 score as a function of the confidence factor β. White circle denotes the maximal value. F, H. Inferred versus true selection coefficients of individual lineages. Lineages are called adapted with β = 3.3 (see main text). Each symbol corresponds to a lineage; orange circles, black upward triangles and blue downward triangles represent true positives, false positives and false negatives, respectively; true negatives are not displayed for clarity.