Dual-channel graph learning reveals similarity and complementarity in protein-protein interaction networks
Fig 5
The interpretability provided by DMG-PPI.
(A) Surface representation of a protein complex (UniProt IDs: O76528 and P41240). The likelihood of a residue being a hotspot is visualized using a color gradient from low (green) to high (red). (B) DMG-PPI accurately identifies the interaction mode between proteins. Dashed lines represent the prediction computed by DMG-PPI, while solid lines represent ground-truth. The modes of PPIs are represented by edge color, varying along a spectrum from blue (similarity-driven) to red (complementarity-driven).