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Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias

Fig 5

Locking zones across different models and an implied strategy for suppressing PVCs.

(A) Locking zones in the oscillator model with a piecewise linear PRC, shown as a function of and . Inset numbers indicate the locking ratio N:M, and colors represent the period N; “Period 0” refers to aperiodicity or N . The dashed box highlights the region also examined in the ionic model. (B) Locking zones in the ionic model as a function of sodium channel conductance. Similar locking regions appear in the oscillator model with a linear PRC (dashed box). (C) Locking zones in the oscillator model using the empirical PRC. (D) Locking zones in the modulated parasystole model, using the same PRC and other parameters derived from patient data. The white line indicates the range of 𝜏 values observed in the patient record. (E) Percentage of PVCs observed in the modulated parasystole model fit with patient data. (F) Percentage of PVCs averaged over 𝜏, shown as a function of and (conduction time into and out of the ectopic focus). The white dot marks parameter values fit to the patient. The white arrow indicates the direction associated with a reduced PVC burden.

doi: https://doi.org/10.1371/journal.pcbi.1013935.g005