Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias
Fig 4
Phase resetting in a computational model for human iPSC-CMs.
(A) Schematic representation of the ionic currents in the human iPSC-CM model (Paci et al, 2020). (B) Top: Trace of a full action potential cycle (black), overlaid with action potentials evoked by stimuli applied at incrementally increasing times (every 30 ms; traces color-coded by stimulus phase). Bottom: Corresponding phase response curve (PRC). (C) Sensitivity of the PRC discontinuity () to ionic current magnitudes (magnitude of 1 corresponds to default value). Left:
as a function of current magnitude. Right: Change in
following a
change in the conductance of each current (shaded: -30%, opaque: + 30%).