SHADE: A multilevel Bayesian framework for modeling directional spatial interactions in tissue microenvironments
Fig 6
SIC showing the directional association of CAFs (source) with CTLs (target), stratified by patient group.
Solid lines show cohort-level estimates for CLR and DII; dashed lines show patient-level SICs, illustrating hierarchical variability across patients within each cohort. CTLs in CLR patients exhibit avoidance of CAFs, while DII patients show neutral to clustering patterns, indicating group-specific spatial organization.