Synthetic data enables human-grade microtubule analysis with foundation models for segmentation
Fig 6
SAM3Text + HPO closely matches ground-truth MT length and curvature distributions across scales and datasets.
Normalized histograms compare predicted and ground-truth distributions for MT length (top row) and curvature (bottom row) on (a) SynthMT and (b) unseen, real data. SAM3Text + HPO preserves both low and high values across the full range of lengths and curvatures, as reflected by low KL divergence values computed from these histograms. Distributions for the other methods on SynthMT are shown in Fig E in S1 Appendix and Fig F in S1 Appendix.